Valuation: Silence Therapeutics plc

Market Cap 888M 1.19B 1.06B 980M 1.66B 113B 1.69B 11.68B 4.69B 59.39B 4.46B 4.37B 187B P/E 2026 *
-38.7x
P/E 2027 * -31.9x
Enterprise Value 753M 1.01B 904M 831M 1.41B 95.82B 1.43B 9.91B 3.98B 50.4B 3.79B 3.71B 159B EV / Sales 2026 *
2,291x
EV / Sales 2027 * 936x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
1 day-0.25%
1 week+0.41%
1 month+80.70%
3 months+88.27%
6 months+170.18%
Current year+224.84%
1 week 19.65
Extreme 19.65
19.86
1 month 8.66
Extreme 8.66
19.86
Current year 4.19
Extreme 4.19
19.86
1 year 4.19
Extreme 4.19
19.86
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap. Importance
6/7/26 Sell 865,112 0.6105%
2/1/26 Free

Chief Financial Officer

375,000 0.2646%
2/1/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-0.25%+0.41%+175.84%+194.78% 1.19B
-0.62%-1.87%+42.87%+64.15% 63.77B
+0.35%+3.20%+14.40%+81.76% 56.37B
+0.53%+1.96%+16.24%+103.35% 54.62B
-2.81%-4.31%+23.50%+47.83% 44.06B
-0.33%-1.93%+19.28%+98.80% 42.11B
+0.55%+2.31%+225.14%+866.21% 41B
+3.27%+47.96%+112.84%+96.58% 34.92B
+1.22%-1.44%+14.57%+46.95% 32.82B
+0.89%+20.55%-40.62%+349.24% 24.7B
Average +0.28%+6.83%+60.40%+194.97% 39.55B
Weighted average by Cap. +0.18%+5.43%+48.38%+176.72%

Financials

2026 *2027 *
Net sales 329K 440K 394K 363K 615K 41.82M 626K 4.33M 1.74M 22M 1.65M 1.62M 69.38M 760K 1.02M 912K 839K 1.42M 96.73M 1.45M 10.01M 4.02M 50.88M 3.82M 3.74M 160M
Net income -42.57M -57.03M -51.08M -46.99M -79.58M -5.42B -81.07M -560M -225M -2.85B -214M -209M -8.98B -64.86M -86.89M -77.82M -71.58M -121M -8.25B -124M -854M -343M -4.34B -326M -319M -13.69B
Net Debt -134M -180M -161M -148M -251M -17.09B -256M -1.77B -710M -8.99B -676M -661M -28.36B -176M -235M -211M -194M -329M -22.36B -335M -2.31B -929M -11.76B -884M -865M -37.09B
Projected Income Statement - Annual - Silence Therapeutics plc
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
30/10/26 US$19.75 -0.25% 621,426
29/10/26 US$19.80 +0.46% 1,814,667
28/10/26 US$19.71 -0.35% 2,757,826
27/10/26 US$19.78 -.--% 1,488,216
26/10/26 US$19.78 +0.56% 4,654,224
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
MarketScreener Ratings - Silence Therapeutics plc
Sell
Consensus
Buy
Mean consensus
OUTPERFORM
Number of Analysts
5
Last Close Price
19.75USD
Average target price
19.75USD
Spread / Average Target
-.--%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Silence Therapeutics plc