Valuation: Silence Therapeutics plc

Market Cap 556M 750M 650M 614M 1.04B 71.96B 1.05B 7.33B 2.82B 36.49B 2.82B 2.76B 116B P/E 2026 *
-23.4x
P/E 2027 * -18.8x
Enterprise Value 423M 571M 494M 467M 794M 54.75B 800M 5.58B 2.15B 27.76B 2.14B 2.1B 88.53B EV / Sales 2026 *
1,313x
EV / Sales 2027 * 509x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Silence Therapeutics plc

1 day-4.59%
1 week-8.98%
Current month-7.91%
1 month-9.18%
3 months+78.00%
6 months+80.58%
Current year+104.93%
1 week 12.1
Extreme 12.1
13.81
1 month 12.1
Extreme 12.1
15.28
Current year 4.19
Extreme 4.19
17.58
1 year 4.19
Extreme 4.19
17.58
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap. Importance
6/7/26 Sell 865,112 0.6105%
2/1/26 Free

Chief Financial Officer

375,000 0.2646%
2/1/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-4.59%-8.98%+163.42%+25.23% 750M
+0.56%-3.38%-1.83%+8.00% 45.81B
-0.12%-1.19%+343.42%+545.03% 43.91B
+1.51%+4.04%+45.01%+27.38% 44.39B
-2.07%-1.42%+4.28%+72.97% 39.4B
-0.73%-3.06%+9.63%+38.92% 31.26B
-9.49%-11.23% - - 15.75B
+4.21%+5.01%+24.99%+121.62% 17.32B
+1.83%+3.20%+16.49%+32.73% 14.73B
-0.08%-2.81%+79.24%+31.27% 13.03B
Average -0.90%-1.98%+76.07%+100.35% 26.63B
Weighted average by Cap. -0.27%-1.25%+76.99%+130.17%

Financials

2026 *2027 *
Net sales 322K 435K 377K 356K 605K 41.71M 610K 4.25M 1.64M 21.15M 1.63M 1.6M 67.45M 751K 1.01M 877K 829K 1.41M 97.09M 1.42M 9.89M 3.81M 49.23M 3.8M 3.72M 157M
Net income -42.14M -56.82M -49.22M -46.54M -79.08M -5.45B -79.68M -555M -214M -2.76B -213M -209M -8.81B -71.01M -95.76M -82.95M -78.44M -133M -9.19B -134M -936M -360M -4.66B -360M -352M -14.85B
Net Debt -133M -179M -155M -147M -250M -17.22B -252M -1.75B -675M -8.73B -674M -659M -27.84B -174M -235M -203M -192M -327M -22.51B -329M -2.29B -883M -11.42B -882M -862M -36.41B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
15/09/26 US$12.46 -4.59% 1,383,436
14/09/26 US$13.06 +0.31% 1,095,255
11/09/26 US$13.02 -2.18% 685,914
10/09/26 US$13.31 -1.77% 682,632
09/09/26 US$13.55 -1.02% 645,880
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
12.46USD
Average target price
33.00USD
Spread / Average Target
+164.85%

Quarterly revenue - Rate of surprise

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