Valuation: Septerna, Inc.

Market Cap 1.89B 1.68B 1.56B 1.41B 2.64B 179B 2.68B 18.72B 7.41B 93.81B 7.08B 6.93B 296B P/E 2026 *
-29.9x
P/E 2027 * -17.7x
Enterprise Value 1.51B 1.35B 1.24B 1.13B 2.11B 143B 2.14B 14.95B 5.92B 74.91B 5.65B 5.53B 236B EV / Sales 2026 *
15.7x
EV / Sales 2027 * 19.1x
Free-Float
99.2%
Yield 2026 *
-
Yield 2027 * -
1 day-1.15%
1 week+11.17%
Current month+3.27%
1 month+5.10%
3 months+20.73%
6 months+61.83%
Current year+44.94%
1 week 36.04
Extreme 36.035
41.77
1 month 34.36
Extreme 34.36
41.77
Current year 22.78
Extreme 22.78
51.1
1 year 17.55
Extreme 17.55
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 01/11/2021
Director of Finance/CFO 55 06/01/2025
President 58 01/08/2025
Director TitleAgeSince
Director/Board Member 60 01/11/2021
Chairman 50 01/11/2021
Director/Board Member 41 01/11/2021
Date Insider Type Main position Quantity % Market Cap. Importance
8/9/26 Free

Chief Technology Officer

275,000 0.5892%
1/9/26 Exercice

Executive/Senior Manager

9,999 0.0214%
12/8/26
RA Capital Management LP
SellCompany -1,493,000 3.3122%
Change 5-day change 1-year change 3-year change Capi.($)
-1.15%+11.17%+85.45% - 1.89B
+2.41%+0.29%+42.02%+71.57% 64.69B
-0.15%+7.50%+11.01%+73.48% 54.78B
+0.57%+4.60%+10.07%+92.86% 53.49B
+0.37%+4.67%+27.03%+52.07% 45.98B
-1.21%+2.32%+21.80%+123.81% 42.94B
-0.37%+5.07%+249.91%+918.74% 40.08B
+0.05%+0.21%+18.26%+58.53% 33.52B
-0.38%+5.68%+36.43%+27.54% 23.67B
+1.19%-4.98%+29.01%-0.65% 23.97B
Average +0.13%+3.29%+53.10%+157.55% 38.5B
Weighted average by Cap. +0.38%+2.77%+47.76%+158.58%

Financials

2026 *2027 *
Net sales 96.14M 85.85M 79.31M 71.87M 134M 9.13B 137M 954M 378M 4.78B 361M 353M 15.07B 73.64M 65.76M 60.75M 55.05M 103M 6.99B 105M 731M 289M 3.66B 276M 270M 11.55B
Net income -61.3M -54.74M -50.57M -45.83M -85.73M -5.82B -87.15M -609M -241M -3.05B -230M -225M -9.61B -115M -103M -94.94M -86.03M -161M -10.92B -164M -1.14B -452M -5.72B -432M -423M -18.05B
Net Debt -380M -339M -313M -284M -531M -36.07B -540M -3.77B -1.49B -18.9B -1.43B -1.4B -59.59B -476M -425M -393M -356M -666M -45.21B -677M -4.73B -1.87B -23.69B -1.79B -1.75B -74.68B
Projected Income Statement - Annual - Septerna, Inc.
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. It is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. The Company's Native Complex Platform is designed to enable it to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
23/10/26 US$40.41 -1.15% 200,318
22/10/26 US$40.88 +0.29% 251,111
21/10/26 US$40.76 +3.58% 286,397
20/10/26 US$39.35 +8.16% 418,309
19/10/26 US$36.38 +0.08% 410,191
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
MarketScreener Ratings - Septerna, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
40.41USD
Average target price
54.22USD
Spread / Average Target
+34.18%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Septerna, Inc.
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