Valuation : Septerna, Inc.

Market Cap 1.72B 1.48B 1.39B 1.27B 2.37B 162B 2.38B 16.41B 6.37B 83.1B 6.44B 6.3B 268B P/E 2026 *
-27.2x
P/E 2027 * -16.1x
Enterprise Value 1.34B 1.15B 1.08B 988M 1.85B 126B 1.85B 12.78B 4.96B 64.69B 5.01B 4.91B 208B EV / Sales 2026 *
13.9x
EV / Sales 2027 * 16.8x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
1 day-0.14%
1 week-5.55%
Current month-3.67%
1 month-5.19%
3 months+17.98%
6 months+33.78%
Current year+31.81%
1 week 36.46
Extreme 36.46
39.1
1 month 36.46
Extreme 36.46
51.1
Current year 22.78
Extreme 22.78
51.1
1 year 13.67
Extreme 13.67
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 01/11/2021
President 58 01/08/2025
Director of Finance/CFO 55 06/01/2025
Director TitleAgeSince
Director/Board Member 60 01/11/2021
Chairman 50 01/11/2021
Director/Board Member 41 01/11/2021
Date Insider Type Main position Quantity % Market Cap. Importance
1/9/26 Exercice

Executive/Senior Manager

9,999 0.0222%
12/8/26
RA Capital Management LP
SellCompany -1,493,000 3.3122%
12/8/26
Third Rock Ventures LLC
SellCompany 147,200 0.3266%
Change 5-day change 1-year change 3-year change Capi.($)
-0.14%-5.55%+154.68% - 1.72B
-2.54%-2.84%-1.77%+14.72% 48.93B
-0.40%+1.03%+418.57%+523.39% 45.01B
-1.42%+2.30%+42.67%+21.22% 44.07B
-1.22%-2.31%+4.82%+74.90% 40.73B
+0.53%-1.36%+16.87%+47.12% 33.52B
-0.21%+9.14% - - 17.77B
-0.35%-1.56%+21.42%+123.04% 16.5B
-1.01%+0.50%+13.91%+31.45% 14.67B
-1.65%-1.03%+75.93%+41.22% 13.77B
Average -0.84%-0.07%+83.01%+109.63% 27.67B
Weighted average by Cap. -1.03%+0.08%+89.85%+127.93%

Financials

2026 *2027 *
Net sales 96.06M 82.66M 77.77M 71.04M 133M 9.07B 133M 919M 357M 4.65B 361M 353M 14.99B 73.66M 63.38M 59.63M 54.48M 102M 6.95B 102M 705M 273M 3.57B 277M 271M 11.49B
Net income -61.3M -52.75M -49.63M -45.33M -84.81M -5.79B -85.04M -586M -228M -2.97B -230M -225M -9.57B -115M -99.03M -93.17M -85.11M -159M -10.87B -160M -1.1B -427M -5.57B -432M -423M -17.96B
Net Debt -380M -327M -308M -281M -526M -35.88B -527M -3.64B -1.41B -18.41B -1.43B -1.4B -59.3B -476M -410M -386M -352M -659M -44.97B -661M -4.56B -1.77B -23.07B -1.79B -1.75B -74.33B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
04/09/26 US$36.75 -0.14% 199,666
03/09/26 US$36.80 -1.87% 241,561
02/09/26 US$37.50 -0.48% 263,248
01/09/26 US$37.68 -1.23% 263,952
31/08/26 US$38.15 -1.95% 415,346
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
36.75USD
Average target price
54.22USD
Spread / Average Target
+47.54%

Quarterly revenue - Rate of surprise

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