Valuation : Centessa Pharmaceuticals plc

Market Cap 6.27B 5.41B 5.08B 4.63B 8.71B 595B 8.76B 60.11B 23.4B 303B 23.53B 23.02B 1,003B P/E 2024
-8.13x
P/E 2025 -17.2x
Enterprise Value 6.09B 5.25B 4.94B 4.5B 8.47B 578B 8.51B 58.42B 22.74B 294B 22.87B 22.37B 975B EV / Sales 2024
-
EV / Sales 2025 231,810,355x
Free-Float
78.43%
Yield 2024 *
-
Yield 2025 -
1 day+0.80%
3 months+1.61%
6 months+50.78%
Current year+61.94%
Current year 21.5
Extreme 21.5
40.56
1 year 15.01
Extreme 15.01
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 01/10/2024
Chief Tech/Sci/R&D Officer 55 01/03/2023
Chief Administrative Officer 58 01/04/2021
Director TitleAgeSince
Director/Board Member - 24/06/2026
Director/Board Member - 24/06/2026
Date Insider Type Main position Quantity % Market Cap. Importance
24/6/26
Medicxi Ventures (Jersey) Ltd.
SellCompany -19,963,157 12.9020%
1/5/26 Tax

Chief Executive Officer

-604 0.0004%
26/3/26 Exercice

Executive/Senior Manager

71,994 0.0539%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%-.--%+141.22%+427.34% 6.27B
+0.21%-2.69%+1.19%+17.32% 49.74B
+2.09%-0.71%+452.73%+498.77% 44.98B
-1.09%-0.41%+35.40%+15.17% 42.52B
-0.26%-4.71%+17.19%+71.67% 40.78B
-0.48%-0.84%+16.25%+49.80% 32.89B
-1.06%+2.87% - - 17.09B
-1.81%-5.02%+22.65%+113.24% 16.28B
-1.35%-3.40%+10.13%+26.34% 14.4B
-2.05%-5.14%+72.89%+34.69% 13.48B
Average -0.66%-2.01%+85.51%+139.37% 27.84B
Weighted average by Cap. -0.47%-2.18%+97.75%+129.61%

Financials

2024 2025
Net sales - 15 12.94 12.17 11.09 20.85 1.42K 20.96 143.89 56 724.15 56.32 55.1 2.4K
Net income -236M -203M -191M -174M -328M -22.37B -329M -2.26B -880M -11.38B -885M -866M -37.74B -198M -170M -160M -146M -275M -18.75B -276M -1.89B -738M -9.54B -742M -726M -31.62B
Net Debt -364M -314M -296M -269M -506M -34.58B -509M -3.49B -1.36B -17.59B -1.37B -1.34B -58.32B -176M -152M -143M -130M -245M -16.72B -246M -1.69B -658M -8.51B -662M -647M -28.21B
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
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