Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 9.35B 8.21B 7.63B 7B 13.16B 900B 13.36B 90.65B 35.41B 442B 35.08B 34.33B 1,530B P/E 2026 *
-15.7x
P/E 2027 * -31.9x
Enterprise Value 9.09B 7.99B 7.43B 6.82B 12.81B 876B 13B 88.2B 34.46B 431B 34.14B 33.4B 1,489B EV / Sales 2026 *
10.2x
EV / Sales 2027 * 6.64x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: ISIS Pharmaceuticals, Inc.

Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.35B
+1.15%-2.44%-2.48%+9.93% 46.86B
+0.25%+1.65%+399.22%+647.65% 40.23B
-0.27%+4.45%+11.81%+60.81% 36.23B
+0.35%+0.87%+4.46%-10.31% 34.72B
+3.14%+1.02%+4.76%+43.00% 27.89B
-0.73%+11.84%+34.39%+134.44% 16.79B
+0.47%-2.74% - - 16.74B
+1.27%-5.43%+2.78%+8.28% 13.12B
-2.68%-2.49%-11.36%-34.51% 12.7B
Average +0.43%+0.83%+55.45%+107.41% 27.25B
Weighted average by Cap. +0.57%+0.91%+74.95%+137.80%

Financials

2026 *2027 *
Net sales 890M 782M 727M 667M 1.25B 85.73B 1.27B 8.63B 3.37B 42.15B 3.34B 3.27B 146B 1.39B 1.22B 1.14B 1.04B 1.96B 134B 1.99B 13.51B 5.28B 65.94B 5.23B 5.12B 228B
Net income -596M -524M -487M -447M -840M -57.41B -852M -5.78B -2.26B -28.22B -2.24B -2.19B -97.58B -283M -249M -231M -212M -399M -27.26B -405M -2.75B -1.07B -13.4B -1.06B -1.04B -46.34B
Net Debt -252M -221M -206M -189M -355M -24.27B -360M -2.44B -955M -11.93B -946M -926M -41.26B -101M -88.7M -82.49M -75.7M -142M -9.73B -144M -980M -383M -4.78B -379M -371M -16.53B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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