Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 8.93B 7.85B 7.33B 6.72B 12.58B 855B 12.89B 86.86B 33.97B 423B 33.53B 32.8B 1,463B P/E 2026 *
-15x
P/E 2027 * -29.3x
Enterprise Value 8.54B 7.5B 7B 6.42B 12.03B 818B 12.32B 83.01B 32.46B 405B 32.05B 31.35B 1,399B EV / Sales 2026 *
9.19x
EV / Sales 2027 * 6.21x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 8.93B
+0.45%+6.53%+0.59%+14.33% 48.95B
+1.90%+24.70%+27.25%+9.47% 40.75B
-1.60%-1.15%+388.84%+603.70% 38.46B
-0.98%+2.28%+7.02%+45.34% 36.38B
+1.47%+5.82%+5.76%+43.52% 28.45B
-0.94%+0.05% - - 16.62B
+2.44%+10.76%+30.59%+129.56% 16.33B
-1.14%+6.52%-3.80%-29.33% 13.65B
+0.35%+4.17%+4.24%+10.07% 13.56B
Average +0.33%+5.79%+57.56%+103.33% 28.13B
Weighted average by Cap. +0.27%+6.92%+71.96%+122.81%

Financials

2026 *2027 *
Net sales 929M 816M 762M 699M 1.31B 88.95B 1.34B 9.03B 3.53B 44.02B 3.49B 3.41B 152B 1.4B 1.23B 1.15B 1.05B 1.97B 134B 2.02B 13.62B 5.33B 66.36B 5.26B 5.14B 229B
Net income -602M -529M -493M -453M -848M -57.63B -869M -5.85B -2.29B -28.52B -2.26B -2.21B -98.59B -332M -292M -273M -250M -468M -31.84B -480M -3.23B -1.26B -15.76B -1.25B -1.22B -54.47B
Net Debt -396M -348M -324M -298M -557M -37.89B -571M -3.85B -1.5B -18.75B -1.49B -1.45B -64.81B -241M -211M -197M -181M -339M -23.05B -347M -2.34B -915M -11.41B -904M -884M -39.44B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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ESG MSCI
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